Spittal Road in Rutherglen has been closed in both directions after a van and a motorbike collided.
The motorcyclist has been rushed to hospital following the crash shortly after 7:30am.
Police are at the scene directing traffic and drivers have been advised to avoid the area.
A spokeswoman for Police Scotland said: “There was a collision between a motorbike and a van which was reported to us at 7:35am.
“The driver of the motorbike has been taken to Queen Elizabeth University Hospital.
“The road has been closed in both directions and officers are at the scene directing traffic.
“Drivers should seek alternative routes.”
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